UNLOCK: Unlock this item by defeating Mother in the Corpse II as Eve, When used, this item does a shout-type attack, with its effect increasing in damage and size the more charges you have, Larynx can be used with any number of charges. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. The locust fly will do different things for each harbinger - e.g. While playing as him Anima Sola will always target Dark Esau. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. satanic, star, red, black, Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby, Bombs will also synergize with other bomb items and tear modifiers, including Sad Bombs, Mr. Mega and many more, REPENTANCE - Dr. Fetus bombs now scale with the player's tear size and are now immune to knockback from their own explosions. for example is one of the better ones and beating Greedier with Tainted Isaac wasnt too difficult. soul or black hearts, Your devil deal chance isn't ruined by this item taking away red hearts. The second piece drops after beating the Boss Rush as long as you are holding the first Broken Shovel piece (see previous 2 items for full details), After The Forgotten is unlocked, using it on the mound of dirt again just spawns a random type of chest, Each time you get hit, you drop a coin or two, REPENTANCE - No longer guaranteed to drop coins as The Keeper, UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll), * , the lost item pool, cent, gold, water, wet, blue, While held, Isaac has a significantly higher chance to find drops when breaking poops, Lowers your spacebar item charge rate by 1, Cannot lower the charge of your spacebar item below 1 room, For example, you will now be able to use a 3 room charge item after 2 rooms instead, Does the teleport effect every time you use your current spacebar item, Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms), Higher chance for champion enemies while held, Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance, Does not attract other pickups like the full Magneto item does, Increases your chances to find an Angel Room instead of a Devil Room, Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. I just unlocked the Holy Brimstone and hopefully that will give more wiggle room for other unlocks. . UNLOCK: Unlock this item by defeating Mother in the Corpse II as ??? This will deviate you from the alt path if you are currently on it, Since this item resets your stats, this item can remove Broken Hearts, UNLOCK: Unlock this item by defeating Greedier Mode as Jacob & Esau, Item Pool: Angel Room, Greed Mode Angel Room, Upon use, allows you to consume 1 key and fire it at an enemy, piercing enemies and dealing significant damage, The damage done by the key projectile pierces through enemies and scales with your damage upgrades (x5 damage + 30), Keys fired by this item can open locked doors/chests, secret rooms and destroy objects in the room, such as rocks, Cannot be used if you don't have any keys, Enemies killed by Sharp Key have a ~10% chance to spawn random items that appear in a chests. See the Broken Shovel / Mom's Shovel items for more information on how to unlock, Rotten Hearts fill up a whole container the same as normal red hearts, or the rightmost heart if you're at full health, Every time you clear a room, you'll spawn 2 Blue Flies for each Rotten Heart you currently have, UNLOCK: Unlock this by entering the Corpse floor for the first time, Spawns 2-3 pills, black/bone hearts and/or bombs when picked up, Can spawn in place of a regular sack, including in Shops for 7c, Only one heart can spawn per sack as a maximum, UNLOCK: Unlock this by defeating Mega Satan as Tainted Judas, 48 Hour Energy - Fully recharges your active item and drops 1-2 battery pickups. When used in the backwards path after picking up Dad's Note, R key will skip you to the Basement 1 version of this path, which leads directly to the Home floor. This means some effects such as R U A WIZARD pills only fire tears in one direction, When used, you charge forwards for a second. This may cause you to skip floors where you left a trinket to spawn a Cracked Key. THEGHOST. Use the key to stab the door open and you'll head down to Corpse. Mulligan can be hit by enemy projectiles, making him a good shield, Enemies will sometimes target the Mulligan if he is closer, * item room, treasure room, item room pool, sad, baby, lumpy, brown, pink, When used, makes Isaac leap in the air, similar to the leaper enemies, Maintains momentum if you are already moving in the same direction, If you already have an item which gives you flying, this item becomes a dash effect instead, Can be used in the Isaac boss fight to jump over the beams of light he spawns, * library pool, library room, book room pool, item room, treasure room, item room pool, This mechanic is very useful on Greed and Greedier modes, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Keeper, *, orange, brown, yellow, gold, coin, cent, Upon use this item hurts Isaac without actually taking health away, allowing you to activate any items which trigger when taking damage without losing health, UNLOCK: Unlock this item by defeating Delirium on The Void floor with Eve, When used, this item permanently removes one of your red heart containers and gives you a flat +0.2 Damage Up, the Anemic effect (+1.5 Range Up + red creep trail) and a Cube of Meat, The Anemic effect will only last for the current room, but the Cube of Meat and Damage Up are both permanent, Only works for red hearts and has no effect when used if you only have soul/black hearts, Has no recharge time and can be used as often as you like, It is possible to generate multiple meatboys by stacking more than 4 Cubes of Meat, When used, this item gives you the effect of a random item for the rest of the room, Using this item multiple times in the same room will replace the previous item's effect with a new one, Certain items can be activated with this item which have unexpected effects and many items will do nothing, Items do not grant consumable drops which would normally occur when that item is picked up, Most flight-granting items have cosmetic effects only, and will not allow you to fly, Items that usually give HP up will not give extra health when gained from Metronome, UNLOCK: Unlock this item by defeating Greedier Mode with Eden, This dice allows you to press the Drop key to cycle between all possible dice effects and pick one to use, Charge time scales based on the chosen dice, updating every time you use it, Possible dice include: D1, D4, D6, D8, D10, D12, D20, D100. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. (Does not change your trinkets, pills or cards), 2 Dot - Rerolls all pickups in the room. ?? Having a golden version of this trinket counts as 2 keys. This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. It's an Angel Room version of Brimstone/Maw of the Void, which is as good as it sounds. Explosion damage has increased to 100 (from 60). However, some are a little more hidden, including what might be Repentance's most interesting series of unlocks. Deflected tears turn into homing tears and fire back at enemies, dealing 2 damage. The recharge time of this item depends on the Rune/Soul Stone held: 2 rooms: Rune of Ansuz, Rune of Berkano, Rune of Hagalaz, Soul of Cain, 3 rooms: Rune of Algiz, Blank Rune, Soul of Magdalene, Soul of Judas, Soul of ?? Item Pool: Item Room, Devil Room, Library, * item room, treasure room, item room pool, devil pool, devil room pool, devil deal, book, brown, blue, monster manuel, manaul, Upon use, the dead sea scrolls gives a random spacebar item effect, An item that can be found in the Angel room. 12 Revelation. Dinner = +0.5 tears, +0.2 shot speed. The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). 8 coins = Slot Machine, While playing as Tainted Cain you get a visual interface to see what items are in the bag, allowing you to see what item will be created and swap out specific consumables, Has other uses - Will deal 3 damage to enemies it hits, and can be used to quickly push bombs and objects across rooms, Tainted Cain starts with this item, but can be used by any character after unlocking it and finding it in the item room, Cannot be used to craft another Bag of Crafting, UNLOCK: Unlock this item by defeating Delirium as Tainted Cain, While holding flip, a ghost item will appear behind item pedestals upon entering Item Rooms and Shop that cannot be interacted with, When activated, all real items in the room will be swapped with the ghost items behind them, The ghost item stays there even if you take the regular item, allowing you to use Flip to get both of them, Does nothing with item pedestals that don't have a ghost item behind them, When playing as Tainted Lazarus, activating Flip also changes you between Lazarus and Dead Lazarus, Tainted Lazarus starts with this item, but can be used by any character after unlocking it and finding it in the item room, UNLOCK: Unlock this item by defeating Delirium as Tainted Lazarus, When used, gives you an orbital flame which represents another random passive item in the game. ?, Soul of the Lost, 4 rooms: Rune of Ehwaz, Rune of Perthro, Black Rune, Soul of Isaac, Soul of Eve, Soul of Eden, Soul of the Forgotten, Soul of Jacob and Esau, 6 rooms: Rune of Dagaz, Soul of Samson, Soul of Azazel, Soul of Apollyon, Soul of Bethany, 12 rooms: Rune of Jera, Soul of Lilith, Soul of the Keeper, Tears have a chance to fire a fungus tear that sticks to enemies. Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. Basement 2: 2 Bombs + 2 Keys, Caves 1: 1 Boss Item. Depths 2: 20 coins, Sheol: 1 Devil Room Item + 1 Black Heart. * boss room pool, boss room item, mr. squeezy, mr squeezy, cobaltstreak, white, brown, red, bow, * boss room pool, boss room item, purple, carton, grape drank, When picked up, spawns 1 red heart, 1 key, 1 bomb, 1 coin, 1 card/rune, 1 pill and 1 trinket, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, brown, orange, cardboard, Doubles the yield of hearts, coins, bombs and keys that spawn from non-red chests, Item Pool: Shop, Challenge Room, Key Beggar, Mom's Chest, * key master pool, key beggar pool, key judgement pool, , dungeon room, blood challenge room, arena pool, shop room pool, shop item pool, golden, horns, moms key, mom key, Tears have a random chance to charm enemies, Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac, The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, The Planetarium is a special rare Item Room that is more likely to appear whenever you don't enter an Item Room in a previous floor. Those tears will cause the same effect if they happen to hit other enemies, Effects that replace your tears such as Brimstone simply have a chance to apply this effect, Any enemies that come within close range of Isaac will become feared, which causes them to flee, When used, this item takes away 5 of your coins and gives a +1.2 Damage Up that lasts for the current room, Can stack as many times as you want. For everything it increases by 1 coin * the number of purchases, The max price of an item is always 99c with this item, Works with Keeper's Box and the Member Card extra shop, Most spider enemies no longer target or deal contact damage to Isaac, This is very similar to a Skatole for spiders instead of flies, Continuously firing or charging tears for 3 seconds causes Isaac to fart and drop a Butt Bomb, Only 1 Butt Bomb can be dropped per charge, so you'll need to stop firing then start again to drop another one, Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time, *, yfront, y-front, underpants, underwear, white, grey, gray, no 2, number two, number 2, no two, Transforms Isaac's tears into a wide arc shape which doubles their size and hitbox, *, flat, white, grey, gray, blue, drip, water, eyes, This item turns all doors that require a key into doors which need a coin to enter instead, This affects shops, item rooms, libraries, double locked doors, key blocks, chests and other key doors, Changes the appearance of doors and objects that this item works on to show a coin slot instead of a keyhole, Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop, *, grey, gray, metal, slot, rectangle, silver, Gives you a random item at the start of your next run (You need to start a fresh run to receive the item), Important progression items such as Key Pieces or the Mom's Shovel pieces cannot be given by Eden's Blessing, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eden, When used, can be thrown at enemies to capture them (similar to a Pok Ball), After capturing an enemy, the next use of the Friendly Ball will re-spawn the same enemy as a friendly companion which will attack other enemies, The companion will persist between rooms and floors until it dies by taking enough damage, Walking over the thrown ball after capturing an enemy will immediately recharge it, *, pokemon, grey, gray, blue, deathstar, circle, When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head, Luck-based items such as Holy Light are applied to each tear individually, Gives Isaac a familiar Gurdy that will charge around the room dealing contact damage to enemies, The Gurdy is charged by holding down the fire button and letting go. shop room pool, shop item pool, cross, brown, Upon use, gives +2 damage up which lasts for the current room, x1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers), Increases your chances of getting a devil/angel room by +12.5%, REPENTANCE - The effect stacks if used multiple times, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, starting yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. Effect persists between rooms while the time period is active, Speed Down - Reduces your speed stat by -0.12, Speed Up - Increases your speed stat by +0.15, Tears Down - Reduces your tears stat by -0.28, Tears Up - Increases your tears stat by 0.35, Telepills - Teleports you to a random room when used. Hook Worm, Wiggle Worm etc. I've played Repentence on PC and will be getting it again when the EU switch version drops. princezzxdiana, pink, purple, hat, Once per room when you are damaged down to your final half a heart, you gain 1 soul heart, Re-entering a room allows this effect to be triggered again, REPENTANCE - Scapular won't grant its soul heart if the player is attempting to proc it with certain heart donation mechanics (such as IV Bag), * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, "The Binding of Isaac: Rebirth". uses as his main mechanic, Killing or damaging enemies spawns various poops, which add to his collection. spray, brown, white, yellow, moms purfume, Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack, Partial charging does nothing - must be fully charged to use, * item room, treasure room, item room pool, pink, body part, monstros lung, On pickup Abaddon converts all your heart containers to black hearts, then gives you +2 more black hearts, Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period, REPENTANCE - No longer kills Keeper when picked up, just reduces coin health to 1, UNLOCK: Unlock this item by beating the Chest with Azazel, * devil pool, devil room pool, devil deal, red devil sign, abandon, abadon, pentagram, Isaac leaves a trail of tar behind him which will slow down enemies that walk over it, Tears have a chance to slow enemies and their projectiles for a short period of time, The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck, * item room, treasure room, item room pool, black, grey, gray, The Stop Watch applies a permanent but slight slowing effect to all enemies and their projectiles, The slowing effect has a reduced effect against Brimstone lasers fired by enemies, REPENTANCE - Stop Watch now slows down all enemies in the game once again, but the slow effect is much less drastic. Curse of the Lost), Black Candle removes the teleportation effect of Cursed Eye, +15% chance of a devil or angel room opening after the boss fight, UNLOCK: Unlock this item by donating 150 pennies to the Shop, * curse room pool, shop room pool, shop item pool, grey, gray, Gives Isaac high damage tears with a short range, Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does, Tear damage starts at triple (300%) and decreases over range to eventually be 0%, * item room, treasure room, item room pool, red, bloody, eyeball, If the total sum of all your health is at one heart after taking damage, the necronomicon effect will activate, dealing 40 damage to the entire room, REPENTANCE - Missing Page 2 now doubles all black heart and Necronomicon damage (to 80 instead of the usual 40), Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper, A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it, If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, His main mechanic, Killing or damaging enemies spawns various poops, best items to unlock isaac: repentance add to collection... 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